A naturally occurring molecule in the human system, nitric oxide, activates an enzyme referred to as cyclic Guanosine monophosphate (cGMP). This enzyme catalyzes a chemical cascade that results in the expansion of arteries around the male genitals. The actions of cGMP are attenuated by another enzyme known as phosphodiesterase (PDE).
Vardenafil hydrochloride actively suppresses PDE, thereby indirectly prolonging the vasodilatory effects of cGMP, and therefore producing a long-lasting erection. It does not however prevent the spread of sexually transmitted diseases, neither does it possess a contraceptive effect. It is exclusively used to boost and maintain an erection.
This medication is non-intoxicating and its effect usually subsides four hours post-intake.
Prominent brand name drugs such as Levitra contain vardenafil as their pharmaceutically active constituent.
Can I buy Vardenafil from an online pharmacy in the US?
This drug cannot be accessed in conventional drugstores without a medic's authorization. This is because Food and Drug Administration (FDA) grouped it as prescription-only drug.
Thanks to technological advancement, online apothecaries stores propose barrier-free substitutes that bridge gaps in the demand and supply of several drugs.
Vardenafil is on the market for sale in online pharmacies. You can buy all doses from credible webpages even without a doctor's prescription. Order will reach you within the US in a short time interval.
How to take 20mg of Generic Levitra (Vardenafil) and duration of effects
Vardenafil comes in two forms: film-coated and orodispersible pills. Both preparations are taken only once within 24 hours.
An hour or half before sexual engagement, 10mg portions are taken with water or other suitable drink of preference, except grapefruit juice which may delay its onset of activities and may predispose to the possibility of coming up with undesirable effects.
Note that 20mg is the maximum daily dose required and it requires sexual inducement to trigger an erection.
How long does it last?
Even though the effectiveness of Vardenafil is related to the dose taken at a time, its operations last the same for low and high strengths.
From the beginning of an erection, its activity lasts 4-5 hours, within this period, penile turgescence is sustained.
In elderly men and persons with compromised hepatic functions, the 20mg dosage is not recommended. Except for these cases, 20mg is generally safe.
Comparison of Levitra with the world's most famous Viagra
Levitra vs Viagra
Levitra and Viagra employ a similar procedure to tackle impotence. Both medications are taken approximately an hour before sex.
Viagra, first introduced in 1998, is by far the most universally accepted solution for erectile defect, Levitra is however more efficacious because only 10mg of it provides equal effects as 50mg of Viagra. Both drugs last about 4-6 hours post-ingestion in the body. Unlike Viagra, Levitra can be orally administered with alcohol.
Levitra and Viagra have similar side effects (including headache, flushing, nose block, gastro-intestinal disturbances, back pain, etc) that tend to increase with higher doses. Negative reactions are more frequent with Viagra than Levitra.
Vardenafil vs Sildenafil
A generic variant of Viagra called Sildenafil is approved to treat pulmonary arterial hypertension, while the Genetic-equivalent of Levitra is solely used to alleviate impotence.
Choose the best dosage of Vardenafil that will suit you
Variety of dosages are available on the market in 10mg and 20mg strengths. You can make a choice based on the amount that works for you with few or no side effects.
Men 65 years or older and individuals with a pre-existing record of liver or vascular conditions should consider using a 5mg dose once per diem. When dangerous side effects are encountered with 10mg or 20mg, a lower dosage (5mg) is adopted.
A dose of 10mg is used in many instances to establish a baseline for treatment. At least 76% of participants gave a positive response during the post-marketing review of the 10mg formulation. If the resultant erection is not rigid enough, you may adopt the 20mg tablets. But before you upgrade the dose, it is advisable to try the 10mg formulation at least four separate times.
In a study conducted, 40mg of dose lowered arterial blood pressure by at least 4.3mmHg and caused severe backache. Neurological and heart impairments weren't observed even at higher doses up to 60mg.
How to purchase Vardenafil at the best possible prices
Vardenafil is sold over the counter in traditional retail apothecaries, although a physician's prescription is needed and price is high.
Drug shops online provide more economical pricing and have easier access than local dispensaries.
Health insurance plans and Medicare hardly cover Vardenafil's cost, but you can get it at discounted rates through the following:
- Coupons and rebates: Vardenafil offers may be in the form of a discount coupon, refunds, trial offer, or free samples directly from the manufacturer.
- Patient Assistance Programs: some pharma companies giveaway drugs free or at discounted rates for people with financial constraints or those without insurance.
A tip you might want to consider is to buy a large quantity of the drug, the more you purchase the lesser you pay.
Precautions to reduce side effects of Vardenafil
The following measures and every other precaution mentioned on the drug leaflet should be observed:
- Find the right dose for you depending on your chances of successful intercourse, reactivity, age, and history of hepatotoxicity.
- Avoid taking it with citrate-containing fluids such as grapefruit juice. Citrate potentiates the side effects of vardenafil.
- Do not take it concomitantly with blood-pressure-lowering therapies such as nitrates. Interaction between the two chemical constituents elicits pronounced hypotension.
- Before initial therapy, please makes sure you know the underlying cause of the erectile malfunction.
- Revoke usage of the drug immediately you experience signs of hyperactivity to its primary or secondary compounds.